Quick Answer

You can follow the main story on a first run, but before leaving each chapter, return to camp and check companion tasks, camp requests, and nearby stranger missions. RDR2’s best pacing comes from mixing story and world, not rushing the critical path.

Route Advice

StageFocus
EarlyLearn camp, horses, weapons, and map rhythm
MidgameAdd strangers, treasures, and legendary animals by region
LateCheck Honor, side jobs, and gear before the ending