Quick Answer

For a first run, pick one main weapon that lets you survive consistently, then use the second weapon slot to cover range, part breaks, or status. Do not bounce between all 14 weapons immediately. Learning sheathing, dodging, healing, tracking, and wound damage matters more than theoretical DPS.

Beginner Priority

TypeGood directionWhy it is stable
ForgivingSword and Shield, Lance, safer Switch Axe playEasier healing, guarding, or short-window damage
Direct damageLong Sword, Great Sword, Dual BladesClear goals, but timing matters
Safer rangeBow, Light BowgunComfortable distance, but stamina or ammo matters
Higher ceilingCharge Blade, Insect Glaive, Hunting Horn, Heavy BowgunStrong, but system knowledge matters more

Pairing Two Weapons

Main weaponSecond weapon can cover
Melee mainRange, status, or high body parts
Ranged mainDefense, tail cuts, or close burst
Technical mainA safer fallback weapon
Poor part accessA weapon that reaches the target part better

How To Judge Fit

If greed attacks keep knocking you down, the weapon may be too demanding for your current route. If you survive reliably and only need more time, keep practicing. The real early-game trap is using every weapon a little and mastering none of them.