Quick Answer

Enter Dogtown after your build, cyberware, and main weapon feel stable. Going too early makes dense fights, stealth routes, and elite enemies harder; going too late reduces how much DLC rewards help the rest of the run.

Entry Checklist

ItemRecommendation
BuildHave one reliable damage plan
CyberwareOS, legs, and survival tools should not lag behind
SuppliesAmmo, healing, grenades, or hacking resources are ready
SavesKeep manual saves before major choices